Publications

23 Publications since 2013:

— From the American Chemical Society Journals:

ACS Central Science (2018), ACS Chemical Biology (2016, 2017, 2018), Chemical Reviews (2018), Biochemistry (2013, 2017), Chemical Research in Toxicology (2016), Journal of the American Chemical Society [2013, 2015 (×2), 2016];

— From the Nature Publishing Group:

Nature Chemical Biology (2017, 2018), Nature Protocols (2016), Oncogene (2015);

— From the Cell Press:

Cell Chemical Biology [2017 (×2), 2018]; Trends in Biochemical Sciences (2018);

— From the ChemPubSoc Europe (Wiley-VCH):

ChemBioChem-European Journal of Chemical Biology (2014), Current Protocols in Chemical Biology (2018), BioEssays (2018);


  • Weighing up the selenocysteome uncovers new sec-rets

October 2018Cell Chemical Biology (Preview)

Jesse R. Poganik#, and Yimon Aye*

(#, first author *, corresponding author)


Xuyu Liu#, Marcus J. C. Long#, and Yimon Aye*

(#, co-first authors. *, corresponding author)

September 2018 – Trends in Biochemical Sciences (Review) (electrophile signaling program)


Yuan Fu#, Marcus J. C. Long#, Somsinee Wisitpitthaya, Huma Inayat, Timothy M. Pierpont, Islam M. Elsaid, Jordana C. Bloom, Joaquin Ortega, Robert S. Weiss, and Yimon Aye*

(#, co-first authors. *, corresponding author)

August 2018 – Nature Chemical Biology (Original Research) (nucleotide signaling program)


Saba Parvez#, Marcus J. C. Long#, Jesse R. Poganik, and Yimon Aye*

(#, co-first authors. *, corresponding author)

August 2018 – Chemical Reviews (Review Article) (electrophile signaling program)


Sanjna L. Surya#, Marcus J. C. Long#, Daniel A. Urul, Yi Zhao, Emily J. Mercer, Islam M. Elsaid, Todd Evans, and Yimon Aye*  (#, co-first authors. *, corresponding author)

February 2018 – ACS Chemical Biology (Original Research) (electrophile signaling program)
Invited contribution to the 2018 “Biosensors” Special Issue of ACS Chemical Biology


Alexandra Van Hall-Beauvais#, Yi Zhao, Daniel A. Urul, Marcus J. C. Long, and Yimon Aye*

(#, first author. *, corresponding author)

DOI: 10.1002/cpch.43

February 2018 – Current Protocols in Chemical Biology (Wiley) (Protocols) (electrophile signaling program in cultured cells and C. elegans)


  • Ube2V2 is a Rosetta Stone bridging redox and ubiquitin codes, coordinating DNA damage responses

Yi Zhao#, Marcus J. C. Long, Yiran Wang, Sheng Zhang, and Yimon Aye*

(#, first author. *, corresponding author)

Highlight in Cornell Chronicle

February 2018 – ACS Central Science (Original Research) (electrophile signaling program in cultured cells and in zebrafish)


Jesse R. Poganik#, Marcus J. C. Long#, and Yimon Aye*

(#, co-first authors. *, corresponding author)

February 2018 – BioEssays (Wiley) (Problems & Paradigms) (electrophile signaling program)


Selected as an “ACS Editors’ Choice” communication!
Click Here For LiveSlides Of The Paper

Marcus J. C. Long#, Daniel A. Urul#, Shivansh Chawla#, Hong-Yu Lin+, Yi Zhao+, Joseph A. Haegele, Yiran Wang, and Yimon Aye*

(#, co-first authors. +, co-second authors. *, corresponding author)

Invited contribution to “Future of Biochemistry” Special Issue of ACS Biochemistry (scheduled for January 2018)

September 2017 – Original Research Communication –


Marcus J. C. Long#, Hong-Yu Lin#, Saba Parvez, Yi Zhao, Jesse R. Poganik, Paul Huang, and Yimon Aye*

(#, co-first authors. *, corresponding author)

 Highlighted in Cornell Chronicle: Group discovers avenue for precision cancer treatment

July 22 2017 – Cell Chemical Biology (Original research) (electrophile signaling program)


Marcus J. C. Long#, and Yimon Aye*

(#, first author. *, corresponding author)

May 24 2017 Cell Chemical Biology (Perspective) (electrophile signaling program in cells and fish)


2017 13(3):333-338

Marcus J. C. Long#, Saba Parvez#, Yi Zhao, Sanjna L. Surya, Yiran Wang, Sheng Zhang, and Yimon Aye*

(#, co-first authors. *, corresponding author)

Highlighted in Nature Chemical Biology “News & Views”    2017 13(3):244-245

Highlighted in Cornell Chronicle: Group uses its own ‘toolset’ to probe chemical responses

March 2017 – Nature Chemical Biology (Original Research) (electrophile signaling program in cultured cells and in zebrafish)


  • Subcellular Redox Targeting: Bridging In Vitro and In Vivo Chemical Biology

Marcus J. C. Long#, Jesse R. Poganik§, Souradyuti Ghosh§, and Yimon Aye*

(#, first author. §, shared second-author. *, corresponding author)

January 2017 – ACS Chemical Biology (Review Article) DOI: 10.1021/acschembio.6b01148


Saba Parvez#, Marcus J. C. Long#,  Hong-Yu Lin†, Yi Zhao†, Joseph A. Haegele, Vanha N. Pham, Dustin K. Lee, and Yimon Aye*

(#, co-first authors. †, co-second authors. *, corresponding author)

Nature Protocols 2016 11 2328-2356

December 2016Nature Protocols (electrophile signaling program)


Selected as an “ACS Editors’ Choice” communication!

– peer-reviewed article contributed as part of 2016 ACS CRT young investigator award to Aye Lab

Marcus J. C. Long#, and Yimon Aye*   (#, first author. *, corresponding author)

September 2016 – ACS Chem Res Toxicol (Perspective)- (electrophile signaling program)

Also Selected for the Journal Cover Art !


ACS Chemical Biology (research article) 2016 11 2021-2032

Somsinee Wisitpitthaya#, Yi Zhao, Marcus J. C. Long, Minxing Li, Elaine A. Fletcher, William A. Blessing, Robert S. Weiss, and Yimon Aye*

(#, first author.*, corresponding author)

May 2016ACS Chem Bio (Original Research) (nucleotide signaling program)


Click Here For ACS LiveSlides on the journal webiste

Selected as a Spotlights article on recent JACS publications!

“Chemical Biology On Demand and In High-Definition”

Journal of the American Chemical Society (Spotlights) 2016 138 4269-4269

Journal of the American Chemical Society (Perspective) 2016 138 3610-22

Marcus J. C. Long#,  Jesse R. Poganik, and Yimon Aye*

(#, first author. *, corresponding author)

Feb 2016 – J Am Chem Soc (Perspective) ACS OPEN ACCESS ARTICLE (electrophile signaling program)


Journal of the American Chemical Society (research article) 2015 137 6232-44

Hong-Yu Lin#, Joseph A. Haegele, Michael T. Disare, Qishan Lin, and Yimon Aye*

(#, first author. *, corresponding author)

Apr 2015J Am Chem Soc (Original Research) (electrophile signaling program)


Journal of the American Chemical Society (research communication) 2015 137 10-3

Saba Parvez#, Yuan Fu#, Jiayang Li, Marcus J. C. Long, Hong-Yu Lin, Dustin K. Lee, Gene S. Hu, and Yimon Aye*

(#, co-first authors. *, corresponding author)

Jan 2015 – J Am Chem Soc (Original Research) (electrophile signaling program)


Oncogene (mini review2015  34 2011–2021
Yimon Aye*, Minxing Li#, Marcus J. C. Long and Robert S. Weiss*
(#, first author. *, co-corresponding authors)

Apr 2015 – Oncogene Mini Review (nucleotide signaling program)


ChemBioChem (research article) 2014 15  2598-604

Yuan Fu, Hong-Yu Lin#, Somsinee (Sine) Wisitpitthaya#, William A. Blessing, and Yimon Aye*

(#, co-2nd authors. *, corresponding author)

Aug 2014 – ChemBioChem (Original Research) (nucleotide signaling program)


Biochemistry (research article) 2013 52 7050-9

Yuan Fu#, Marcus J. C. Long, Mike Rigney, Saba Parvez, William A. Blessing, and Yimon Aye*

(#, first author. *, corresponding author)

Sept 2013 – Biochemistry (Original Research)(nucleotide signaling program)


Journal of the American Chemical Society (research communication) 2013 135 14496-9

Xinqiang Fang#, Yuan Fu#, Marcus J. C. Long, Joseph A. Haegele, Eva J. Ge, Saba Parvez, and Yimon Aye*

(#, co-first authors. *, corresponding author)

Sept 2013 – J Am Chem Soc (Original Research) (electrophile signaling program)


PUBLICATIONS DURING TRAINING

From postdoctoral research (MIT, USA):

08/2009 — 06/2012

Original research:

Clofarabine 5´-Di and –Triphosphates Inhibit Human Ribonucleotide Reductase by Altering the Quaternary Structure of its Large Subunit” Yimon Aye and JoAnne Stubbe*; Proceedings to the National Academy of Sciences USA (Direct Submission) 2011, 108, 9815.

Clofarabine Targets the Large Subunit (α) of Human Ribonucleotide Reductase in Live Cells by Assembly into Persistent Hexamers” Yimon Aye, Edward J. Brignole, Marcus J. C. Long, Johnathan Chitturulu, Catherine L. Drennan, Francisco J. Asturias, and JoAnne Stubbe*; Chemistry and Biology 2012, 19, 799.

Mechanistic Studies of Semicarbazone Triapine Targeting Ribonucleotide Reductase in Vitro and in Mammalian Cells: Tyrosyl Radical Quenching Not Involving Reactive Oxygen Species” Yimon Aye, Marcus J. C. Long and JoAnne Stubbe*; Journal of Biological Chemistry 2012, 287, 35768.

“3.3-Å resolution cryo-EM structure of human ribonucleotide reductase with substrate and allosteric regulators bound” Edward J. Brignole, Kuang-Lei Tsai, Johnathan Chittuluru, Haoran Li, Yimon Aye, Pawel A Penczek, JoAnne Stubbe*, Catherine L. Drennan*, Francisco Asturias*; eLife 2018;7:e31502 doi: 10.7554/eLife.31502

From PhD thesis research (Harvard University, USA):

07/2004 — 05/2009

Independent review article:

“Vinyl-, Propargyl- and Allenylsilicon Reagents in Asymmetric Synthesis: Relatively Untapped Resource of Environmentally-Benign Reagents” Marcus J. Curtis-¬Long and Yimon Aye*; Chemistry, A European Journal 2009, 15, 5402.

Original research:

“Structural Report for Sc[(R,R)-norephedrine-pybox](OTf)3 Dimeric Complex” Richard J. Staples* and Yimon Aye; Journal of Chemical Crystallography 2008, 38, 49.

“Aluminum-catalyzed Enantio- and Diastereoselective Carbonyl Addition of Propargylsilanes. A New Approach to Enantioenriched Vinyl Epoxides” David A. Evans* and Yimon Aye; Journal of the American Chemical Society 2007, 129, 9606.

“Enantioselective Scandium-catalyzed Vinylsilane Additions: A New Approach to the Synthesis of β,γ-Unsaturated α-Amino Acid Derivatives” David A. Evans* and Yimon Aye; Journal of the American Chemical Society 2006, 128, 11034.

“Asymmetric, Anti–selective Scandium-catalyzed Sakurai Additions to Glyoxamide. Applications to the Syntheses of N-Boc- D-Alloisoleucine and D-Isoleucine” David A. Evans*, Yimon Aye and Jimmy Wu; Organic Letters 2006, 8, 2071.

From undergraduate master’s thesis research (Oxford University, UK):

10/2003 — 05/2004

“Parallel kinetic resolution of tert-butyl (RS)-3-oxy-substituted cyclopent-1-ene-carboxylates for the asymmetric synthesis of 3-oxy-substituted cispentacin and transpentacin derivatives” Yimon Aye, Stephen G. Davies,* A. Christopher Garner, Paul M. Roberts, Andrew D. Smith and James E. Thomson; Organic and Biomolecular Chemistry, 2018, 6, 2195.

From undergraduate summer research (MIT, USA):

Summer 2003

“Copper-catalyzed Asymmetric Conjugate Reduction as a Route to Novel β-Azaheterocyclic Acid Derivatives” Matthew P. Rainka, Yimon Aye and Stephen L. Buchwald*; Proceedings to the National Academy of Sciences USA, 2004, 101, 5821.